| 產(chǎn)品編號(hào) | bs-43664P |
| 英文名稱 | Recombinant mouse CD133 protein, C-His (HEK293) |
| 中文名稱 | 重組小鼠造血干細(xì)胞抗原CD133蛋白 |
| 別 名 | AC133; Antigen AC133; Hematopoietic stem cell antigen; hProminin; PROM1; Prominin I; Prominin like protein 1 precursor; Prominin mouse like 1; prominin1; PROML1; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4; PROM1_MOUSE; CD133 antigen. |
| 理論分子量 | 63.5kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >1.0mg/ml |
| 純 度 | >80% as determined by SDS-PAGE |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] SWISS: O54990 Gene ID: 19126 一般認(rèn)為，VEGFR2（血管內(nèi)皮生長(zhǎng)因子受體2）是HSCs（造血干細(xì)胞）的特異性的表面標(biāo)志。近來(lái)經(jīng)研究發(fā)現(xiàn)CD133分子是HSCs（造血干細(xì)胞）特異性標(biāo)志。CD133即AC133，是一個(gè)新發(fā)現(xiàn)的HSCs（造血干細(xì)胞）表面標(biāo)志，在HSCs（造血干細(xì)胞）分化成熟過(guò)程中，CD133的含量迅速降低。EPCs(血管內(nèi)皮前體細(xì)胞)區(qū)別于成熟內(nèi)皮細(xì)胞的主要標(biāo)志是CD133。 經(jīng)研究發(fā)現(xiàn)內(nèi)皮細(xì)胞不能結(jié)合CD133的抗體。證實(shí)分化成熟的內(nèi)皮細(xì)胞不具有CD133。這些說(shuō)明CD133可以作為EPCs(血管內(nèi)皮前體細(xì)胞)區(qū)別于 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.
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