| 產(chǎn)品編號(hào) | bs-42367P |
| 英文名稱 | Recombinant human Perilipin-2 protein, N-His |
| 中文名稱 | 重組人脂肪分化相關(guān)蛋白 |
| 別 名 | ADFP; Adipophilin; Adipose differentiation related protein; Adipose differentiation-related protein; PLIN2; PLIN2_HUMAN; adipophilin; Adipose differentiation related protein; ADRP; MGC10598 |
| 理論分子量 | 42.7kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] SWISS: Q99541 Gene ID: 123 Adipophilin（ADFP）是一種脂滴周圍主要的相關(guān)蛋白，它大量分布在脂質(zhì)蓄積正常或不正常的細(xì)胞中，是脂質(zhì)蓄積的一個(gè)特異性標(biāo)記物。它在脂肪細(xì)胞分化早期就有很高的表達(dá)，但當(dāng)脂肪細(xì)胞成熟后，它的表達(dá)就明顯減少，故稱；脂肪分化相關(guān)蛋白。 ADFP在很多組織器官中都發(fā)揮重要作用，它不僅參與脂肪細(xì)胞的脂質(zhì)代謝、脂滴的形成及肝內(nèi)三酰甘油（TO）的合成與代謝，還能促進(jìn)巨噬細(xì)胞、平滑肌細(xì)胞的泡沫化，長(zhǎng)鏈脂肪酸的攝取，乳汁的分泌等。 ADFP的表達(dá)異常與動(dòng)脈粥樣硬化、胰島素抵抗和腫瘤等病理過程密切相關(guān)。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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