| 產(chǎn)品編號 | bs-43691P |
| 英文名稱 | Recombinant human IL2RA (CD25) protein, C-His (HEK293) |
| 中文名稱 | 重組人白介素2受體a鏈蛋白 |
| 別 名 | Interleukin 2 receptor alpha chain; CD 25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL2 RA; IL-2RA; IL2R; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor alpha chain; Interleukin 2 receptor; Ly43; p55; T Cell Growth Factor |
| 理論分子量 | 23.5kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] Gene ID: 3559 CD25抗原是分子量為55KD的單鏈糖蛋白，故又稱白介素2受體。主要用于與淋巴樣腫瘤、自身免疫性疾病及同種異體移植排斥反應(yīng)等疾病的研究。CD25是白介素受體的α亞單位，主要表達(dá)于活化的T細(xì)胞，在活化的B細(xì)胞、NK細(xì)胞和巨噬細(xì)胞也有一定量的表達(dá)。該抗體主要用于標(biāo)記活化的淋巴細(xì)胞。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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