| 產(chǎn)品編號(hào) | bs-43684P |
| 英文名稱 | Recombinant human ROR2 protein, C-His (HEK293) |
| 中文名稱 | 重組人維甲酸相關(guān)孤兒受體α蛋白 |
| 別 名 | Tyrosine-protein kinase transmembrane receptor ROR2; BDB; BDB1; Brachydactyly type B; EC 2.7.10.1; MGC163394; Neurotrophic tyrosine kinase; Neurotrophic tyrosine kinase, receptor related 2; NTRKR2; Receptor tyrosine kinase-like orphan receptor 2; receptor |
| 理論分子量 | 43.7kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
NR1F1;
Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis.
Within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. These isotypes have been shown to differ in only their amino terminus, and their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The structure of the ligand binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth and differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, and migratory capacities of cancer cells. SWISS: Q01974 Gene ID: 4920 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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