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Recombinant mouse SKI protein, GST&His (bs-42424P)  
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產品編號 bs-42424P
英文名稱 Recombinant mouse SKI protein, GST&His
中文名稱 重組小鼠SKI蛋白
別    名 C-SKI; v-SKI; Sloan-kettering viral oncogene homolog; Avian sarcoma viral (v ski) oncogene homolog; C oncogene; C ski; Ski oncogene; Ski oncoprotein; SKV; v ski avian sarcoma viral oncogene homolog; v ski sarcoma viral oncogene homolog; v-ski sarcoma vira  
理論分子量 51.8kDa
性    狀 Liquid
濃    度 >1mg/ml
純    度 >90% as determined by SDS-PAGE
緩 沖 液 20mM Tris-Hcl (pH=8.0) with 8M Urea
保存條件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.

SWISS:
Q60698

Gene ID:
20481

SKI又稱SKI、SKV,經研究發(fā)現SKI蛋白是刺激和誘發(fā)腫瘤生長導致癌癥的關鍵蛋白質之一,SKI蛋白主要通過阻止TGF-β蛋白發(fā)揮作用,當TGF-β蛋白的信號傳導被SKI蛋白阻斷后,細胞就可能加速增值、生長,最終導致癌癥發(fā)生。 有研究表明:c-ski可調節(jié)多種核因子的轉錄活性,參與神經系統(tǒng)發(fā)育、造血細胞的增殖和分化、腫瘤發(fā)生、組織再生等多種生理病理過程,更詳細的作用機制還在進一步研究之中。
產品圖片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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