| 產(chǎn)品編號 | bs-42422P |
| 英文名稱 | Recombinant human SLC22A8 protein |
| 中文名稱 | 重組人陰離子轉(zhuǎn)運(yùn)蛋白-3 |
| 別 名 | Organic anion transporter 3; hOAT3; OAT3; SLC22A8; Solute carrier family 22 member 8; S22A8_HUMAN. |
| 理論分子量 | 43.9kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 50mM Tris-Hcl (pH=8.0) with7mM GSH and 0.1mM PMSF |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Human organic anion transporter (OAT) 3 (SLC22A8) is localized to the basolateral membranes of renal tubular epithelial cells and plays a critical role in the excretion of anionic compounds. Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anions in the kidneys as well as in other tissues such as the liver and brain. Among these families, the OAT family plays the central role in renal organic anion transport. Knowledge of these three families at the molecular level, such as substrate selectivity, tissue distribution, and gene localization, is rapidly increasing. SWISS: Q8TCC7 Gene ID: 9376 OAT3陰離子轉(zhuǎn)運(yùn)蛋白是一類分布廣泛的膜蛋白，通過介導(dǎo)Cl－／HCO－3跨膜轉(zhuǎn)運(yùn)參與細(xì)胞內(nèi)pH、細(xì)胞體積及細(xì)胞內(nèi)氯離子濃度的調(diào)節(jié)。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.
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