| 產(chǎn)品編號(hào) | bs-42419P |
| 英文名稱 | Recombinant human Cadherin-1 protein, N-His |
| 中文名稱 | 重組人鈣粘蛋白1 |
| 別 名 | CDH1; CADH1_HUMAN; CAM 120/80; Epithelial cadherin; Uvomorulin; CD324; CDHE, UVO . |
| 理論分子量 | 27.1kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] SWISS: P12830 Gene ID: 999 細(xì)胞粘附蛋白（Call Adhesion Protein） E-chaherin是研究較多的同質(zhì)粘附分子。E-cadherin的表達(dá)與惡性腫瘤的分化程度、侵襲力、轉(zhuǎn)移負(fù)相關(guān)與預(yù)后正相關(guān)，E-cadherin的低表達(dá)和不穩(wěn)定表達(dá)可促進(jìn)轉(zhuǎn)移的發(fā)生。近年來已成為腫瘤細(xì)胞侵襲和轉(zhuǎn)移研究的熱點(diǎn)之一。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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