| 產(chǎn)品編號(hào) | bs-42338P |
| 英文名稱 | Recombinant human ULK1 protein, N-His |
| 中文名稱 | 重組人自噬相關(guān)蛋白1 |
| 別 名 | ATG 1; ULK1; ATG1; ATG1A; Serine/threonine protein kinase ULK1; Serine/threonine protein kinase Unc51.1; ULK 1; Unc 51 (C. elegans) like kinase 1; UNC 51; Unc 51 like kinase 1; Unc-51-like kinase 1; Unc-51 like kinase 1 (C. elegans); UNC51; ULK1_HUMAN; Se |
| 理論分子量 | 53kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >80% as determined by SDS-PAGE |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non clathrin coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy related (Atg) proteins. SWISS: O75385 Gene ID: 8408 Atg1是一種絲氨酸/蘇氨酸蛋白激酶。Atg1的激脢活性是CVT信號(hào)傳導(dǎo)通路以及細(xì)胞自噬所必須的。Atg1可以和一些執(zhí)行細(xì)胞自噬的蛋白相互作用，而且有很多調(diào)控細(xì)胞自噬的信號(hào)傳導(dǎo)通路匯集在Atg1。因此Atg1可能是一個(gè)可以調(diào)控細(xì)胞自噬很多步驟的一個(gè)調(diào)節(jié)關(guān)鍵點(diǎn)。但在較高等的真核生物中，Atg1的角色仍然不是很清楚。通過目前的研究已經(jīng)比較了解細(xì)胞自噬可以導(dǎo)致細(xì)胞的死亡，但是如何導(dǎo)致死亡的分子機(jī)制還不清楚，有待于進(jìn)一步研究。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.
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