| 產(chǎn)品編號 | bs-1087R |
| 英文名稱 | Rabbit Anti-Angiopoietin 4 antibody |
| 中文名稱 | 血管生成素3/血管生成素4抗體 |
| 別 名 | Angiopoietin 4; AGP4; ANG3; ANG-4; ANG 4; ANGPT4; AGP4; ANGP4_HUMAN. ANG 3; ANG-3; ANG3; Angioarrestin; Angiopoietin 3; Angiopoietin like 1; Angiopoietin like protein 1; Angiopoietin related protein 1; Angiopoietin Y1; Angiopoietin-3; Angiopoietin-like protein 1; Angiopoietin-related protein 1; ANGL1_HUMAN; ANGPT3; ANGPTL1; AngY; ARP1; dJ595C2.2; KIAA0351; UNQ162. |
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Specific References (1) | bs-1087R has been referenced in 1 publications.
[IF=1.922] Wang et al. Angiopoietin-like protein?4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice. (2016) Mol.Med.Rep. 14:3293-300 WB ; Mice.
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| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 54kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANGPT4: 410-503/503 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Subunit: Homodimer; disulfide-linked. Interacts with TEK/TIE2. Subcellular Location: Secreted (Probable). Tissue Specificity: Highly expressed in the lung with much lower levels found in other tissues. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: Q9Y264 Gene ID: 51378 Database links: Entrez Gene: 51378 Human Omim: 603705 Human SwissProt: Q9Y264 Human Unigene: 278973 Human 血管生成素4-ANGPTL4與小血管生成、腫瘤的轉(zhuǎn)移有很重要的關(guān)系。 |
| 產(chǎn)品圖片 |
Tissue/cell: mouse tumor tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-ANGPT3/ANG3/ANGPT4/ANG4 Polyclonal Antibody, Unconjugated(bs-1087R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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