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Rabbit Anti-CX3CL1  antibody (bs-0811R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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50ul/1180.00元
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產(chǎn)品編號 bs-0811R
英文名稱 Rabbit Anti-CX3CL1  antibody
中文名稱 CX3CL1抗體
別    名 C3Xkine; Chemokine C X3 C motif ligand 1; Chemokine CX3C Motif Ligand 1; CX3C membrane anchored chemokine; CXC 3; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; SCYD 1; SCYD1; Small inducible cytokine D1; Small inducible cytokine subfamily D (Cys X3 Cys) member 1; Small inducible cytokine subfamily D member 1; X3CL1_HUMAN.  
Specific References  (4)     |     bs-0811R has been referenced in 4 publications.
[IF=10.392] Wenlong Zhang. et al. Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment. CANCER COMMUN. 2022 May 25  WB ;  Mouse.  
[IF=5.534] Zhang J et al. Dynamic?changes?of?CX3CL1/CX3CR1?axis?during?microglial?activation?and?motor?neuron?loss?in the?spinal?cord?of?ALS?mouse?model. Transl Neurodegener. 2018 Dec 21;7:35.  WB ;  Mouse.  
[IF=5.195] Shan Luo. et al. Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke. J ETHNOPHARMACOL. 2023 May;:116640  IF ;  Rat.  
[IF=2.89] Xie, Wu-Ling, et al. "Abnormal Activation of Microglia Accompanied with Disrupted CX3CR1/CX3CL1 Pathway in the Brains of the Hamsters Infected with Scrapie Agent 263K." Journal of Molecular Neuroscience (2013): 1-14.  WB ;  
研究領域 心血管  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41kDa
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CX3CL1: 301-397/397 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CX3CL1 is a member of the delta chemokine subfamily that contains a unique CX3C cysteine motif near the N-terminal. Unlike other known chemokines, it is a type 1 membrane protein containing a chemokine domain tethered on a long mucin-like stalk. CX3CL1, a leukocyte chemoattractant, is expressed in various tissues including the brain, heart, lung, kidney, skeletal muscle, and testis. The expression is reported to be up-regulated in endothelial cells and microglia by inflammatory signals. CX3CR1, a specific receptor for fractalkine, mediates both leukocyte migration and adhesion.

Function:
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.

Subunit:
Monomer.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted.

Tissue Specificity:
Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.

Post-translational modifications:
A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the intercrine delta family.

SWISS:
P78423

Gene ID:
6376

Database links:

Entrez Gene: 6376 Human

Entrez Gene: 20312 Mouse

Entrez Gene: 89808 Rat

Omim: 601880 Human

SwissProt: P78423 Human

SwissProt: O35188 Mouse

SwissProt: O55145 Rat

Unigene: 531668 Human



神經(jīng)趨化蛋白cx3cl1免疫應答應答及細胞附著,參與細胞因子和趨化因子介導信號轉(zhuǎn)導、免疫細胞趨化性、調(diào)控炎癥應答反應、白細胞附著激活、正調(diào)控鈣非依賴細胞附著。
產(chǎn)品圖片
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CX3CL1 Polyclonal Antibody, Unconjugated(bs-0811R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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