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Rabbit Anti-phospho-GATA6 (Tyr271)  antibody (bs-5375R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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產品編號 bs-5375R
英文名稱 Rabbit Anti-phospho-GATA6 (Tyr271)  antibody
中文名稱 磷酸化GATA結合蛋白6抗體
別    名 GATA6 (phospho Tyr271); GATA6 (phospho Tyr271); Gata binding factor 6; Gata binding protein 6; GATA-binding factor 6; Gata6; GATA6_HUMAN; Transcription factor Gata 6; Transcription factor GATA-6.  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  細胞生物  免疫學  發(fā)育生物學  染色質和核信號  干細胞  轉錄調節(jié)因子  結合蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 60kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human GATA6 around the phosphorylation site of Tyr271: GL(p-Y)SK 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 GATA-6(GATA binding factor 6)is zinc-finger transcription factor that binds DNA at GATA regions; Involved in gene regulation specifically in the gastric epithelium. Cellular localization:Nuclear. Tissue Specificity: gastric epithelium.

Function:
Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation.

Subunit:
Interacts with LMCD1 (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

DISEASE:
Defects in GATA6 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Note=GATA6 mutations have been found in patients with non-syndromic persistent truncus arteriosus (PubMed:19666519).
Defects in GATA6 are the cause of atrial septal defect type 9 (ASD9) [MIM:614475]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Some patients manifest tricuspid valve disease, pulmonary valve disease, and pulmonary artery hypertension.
Defects in GATA6 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Defects in GATA6 are the cause of atrioventricular septal defect type 5 (AVSD5) [MIM:614474]. A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.
Defects in GATA6 are a cause of pancreatic agenesis and congenital heart defects (PACHD) [MIM:600001]. An autosomal dominant disease characterized by pancreatic severe hypoplasia or agenesis, diabetes mellitus, and congenital heart abonormalities including ventricular septal defect, patent ductus arteriosus, pulmonary artery stenosis, truncus arteriosus and tetralogy of Fallot.

Similarity:
Contains 2 GATA-type zinc fingers.

SWISS:
Q92908

Gene ID:
2627

Database links:

Entrez Gene: 2627 Human

Entrez Gene: 14465 Mouse

Entrez Gene: 397600 Pig

Entrez Gene: 29300 Rat

Omim: 601656 Human

SwissProt: P43693 Chicken

SwissProt: Q92908 Human

SwissProt: Q61169 Mouse

SwissProt: Q95JA5 Pig

SwissProt: P46153 Rat

Unigene: 514746 Human

Unigene: 329287 Mouse

Unigene: 8701 Rat



產品圖片
Sample: H9C2(Rat) Cell Lysate at 30 ug Primary: Anti-phospho-GATA6(Tyr271) (bs-5375R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 60 kD
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