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產(chǎn)品編號(hào) bs-5901R
英文名稱 Rabbit Anti-OS9  antibody
中文名稱 OS-9蛋白抗體
別    名 lified in osteosarcoma 9; amplified in osteosarcoma; OS-9; Os9; OS9_HUMAN; Protein OS-9.  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  染色質(zhì)和核信號(hào)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 76kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OS9: 101-200/667 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.

Function:
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.

Subunit:
Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with HSP90B1 and CREB3.

Subcellular Location:
ndoplasmic reticulum lumen.

Tissue Specificity:
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.

Post-translational modifications:
Intramolecular disulfide bonds.
Isoform 1 and isoform 2 are N-glycosylated.

Similarity:
Belongs to the OS-9 family.
Contains 1 PRKCSH domain.

SWISS:
Q13438

Gene ID:
10956

Database links:

Entrez Gene: 10956 Human

Entrez Gene: 216440 Mouse

Entrez Gene: 362891 Rat

Omim: 609677 Human

SwissProt: Q13438 Human

SwissProt: Q8K2C7 Mouse

SwissProt: Q5RKH6 Rat

Unigene: 527861 Human

Unigene: 295246 Mouse

Unigene: 1579 Rat



產(chǎn)品圖片
Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-OS9 (bs-5901CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76 kD Observed band size: 70 kD
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