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Rabbit Anti-GNAQ  antibody (bs-6152R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號(hào) bs-6152R
英文名稱 Rabbit Anti-GNAQ  antibody
中文名稱 G蛋白α亞單位蛋白Q抗體
別    名 G ALPHA q; G protein alpha Q; GAQ; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G q subunit alpha; GNAQ_HUMAN.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GNAQ: 51-150/359 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 GNAQ belong to the family of heterotrimeric Guanine nucleotide-binding proteins proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. GNAQ is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta. in recent studies over expression of GNAQ is associated with cardiomyocyte apoptosis.

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).

Subunit:
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1.

Subcellular Location:
Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Tissue Specificity:
Predominantly expressed in ovary, prostate, testis and colon.

Similarity:
Belongs to the G-alpha family. G(q) subfamily.

SWISS:
P50148

Gene ID:
2776

Database links:

Entrez Gene: 2776 Human

Entrez Gene: 14682 Mouse

Entrez Gene: 654405 Pig

Entrez Gene: 81666 Rat

Omim: 600998 Human

SwissProt: P50148 Human

SwissProt: P21279 Mouse

SwissProt: Q2PKF4 Pig

SwissProt: P82471 Rat

Unigene: 269782 Human

Unigene: 439701 Mouse

Unigene: 441601 Mouse

Unigene: 22817 Rat



Gαq是G蛋白家族成員之一,是Gq蛋白的功能單位。其功能為傳導(dǎo)來(lái)自GPCR的信號(hào)到細(xì)胞內(nèi)。研究證明,Gαq與免疫細(xì)胞活化、增殖、死亡、分化、遷移,細(xì)胞因子分泌以及自身免疫等均有非常密切的關(guān)系。
產(chǎn)品圖片
Sample: SY5Y(Human) Cell Lysate at 30 ug Primary: Anti-GNAQ (bs-6152R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD
Sample: Uterus (Mouse) Lysate at 40 ug Primary: Anti-GNAQ (bs-6152R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD
Sample: Ovary (Mouse) Lysate at 40 ug Primary: Anti-GNAQ (bs-6152R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD
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