| 產(chǎn)品編號 | bs-0514P-Bio |
| 英文名稱 | Recombinant human BMP-2 protein, N-His |
| 中文名稱 | Biotin標(biāo)記的重組人骨形態(tài)發(fā)生蛋白-2 |
| 別 名 | bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2; BMP2A; BMP-2; BMP2_HUMAN; Recombinant human BMP-2 protein, N-His |
| 理論分子量 | 13kDa |
| 檢測分子量 | 17 |
| 性 狀 | Lyophilized or Liquid |
| 純 度 | >95% as determined by SDS-PAGE |
| 緩 沖 液 | Lyophilized from 0.22um filtered solution in 10mM PBS (pH 7.4). Normally 5% trehalose is added as protectant before Lyophilization. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis. 神經(jīng)干細(xì)胞標(biāo)志物 BMP-2主要對未分化間充質(zhì)細(xì)胞和骨系細(xì)胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細(xì)胞向骨形成中心募集，并分化為骨系細(xì)胞，而且可使成纖維細(xì)胞、成肌細(xì)胞及骨髓的基細(xì)胞逆轉(zhuǎn)分化為骨系細(xì)胞。其主要過程是：增加或抑制這些細(xì)胞內(nèi)的某些特異性蛋白的分泌，使成纖維細(xì)胞分化為成骨細(xì)胞，成肌細(xì)胞快速分化為肥大的軟骨細(xì)胞，并促進(jìn)基質(zhì)鈣化。 對于成骨細(xì)胞，BMP-2則可使之維持其特有細(xì)胞表型，并誘導(dǎo)成骨細(xì)胞標(biāo)志物的增高，促進(jìn)細(xì)胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細(xì)胞分化因 |
