| 產(chǎn)品編號 | bs-42210P |
| 英文名稱 | Recombinant human ZO-1 protein, N-His |
| 中文名稱 | 重組胞質(zhì)緊密粘連蛋白1 |
| 別 名 | Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter |
| 理論分子量 | 30kDa |
| 性 狀 | Liquid |
| 濃 度 | >0.5mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 20mM Tris(pH=8.0) with 150mM Nacl |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] SWISS: Q07157 Gene ID: 7082 胞質(zhì)緊密粘連蛋白1（ZO-1）是多結(jié)構(gòu)域蛋白家族膜結(jié)合鳥苷酸激酶的家族成員，在緊密連接蛋白的組成成分中起到對組織分化和器官形成方面起較重要的作用。ZO-1在包括腎、胎盤、血腦屏障等許多組織都有不同的表達，可與緊密連接上的很多跨膜蛋白相互作用。也有學(xué)者認(rèn)為：ZO-1的改變與細(xì)胞通透性的增加有關(guān)。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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