| 產(chǎn)品編號(hào) | bs-41153P-APC |
| 英文名稱 | Recombinant human CD3E protein, His |
| 中文名稱 | APC標(biāo)記的重組人CD3E蛋白 |
| 別 名 | CD3 epsilon; CD3e; CD3e antigen epsilon polypeptide (TiT3 complex); CD3E antigen epsilon polypeptide; CD3E antigen, epsilon subunit; CD3e molecule epsilon; CD3e molecule, epsilon (CD3 TCR complex); CD3e molecule, epsilon (CD3-TCR complex); CD3E_HUMAN; IMD |
| 理論分子量 | 12.5kDa |
| 檢測(cè)分子量 | 34 |
| 性 狀 | Lyophilized or Liquid |
| 純 度 | >95% as determined by SDS-PAGE |
| 緩 沖 液 | Lyophilized from 0.22um filtered solution in 10mM PBS (pH 7.4). Normally 5% trehalose is added as protectant before Lyophilization. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2. CD3 epsilon 參與T淋巴細(xì)胞介導(dǎo),主要用于免疫排斥方面的研究. |
