| 產(chǎn)品編號(hào) | bs-42466P |
| 英文名稱 | Recombinant human MLKL protein, N-GST&C-His |
| 中文名稱 | 重組人混合系列蛋白激酶樣結(jié)構(gòu)域蛋白 |
| 別 名 | hMLKL; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain-like protein; mixed lineage kinase domain like pseudokinase; MLKL_HUMAN. |
| 理論分子量 | 52.9kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 20mM Tris-HCL (pH=8.0) with 8M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. SWISS: Q8NB16 Gene ID: 197259 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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