| 產(chǎn)品編號(hào) | bs-43704P |
| 英文名稱 | Recombinant human CD45 protein, C-His |
| 中文名稱 | 重組人白細(xì)胞共同抗原CD45蛋白 |
| 別 名 | B220; CD 45; CD-45; cd45 antigen; ec3.1.3.48; CD45R; GP180; GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein t |
| 理論分子量 | 64.4kDa |
| 性 狀 | Liquid |
| 濃 度 | >0.5mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | PBS(pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling SWISS: P08575 Gene ID: 5788 CD45在活化信號(hào)轉(zhuǎn)導(dǎo)中起到調(diào)節(jié)作用，在確定CD45為一種PTPase之前就已證實(shí)了CD45參于細(xì)胞的活化和生長調(diào)節(jié)。 抗CD45抗體可以抑制PHA或CD3交聯(lián)所介導(dǎo)的T細(xì)胞增殖，還可抑制NK或細(xì)胞毒性T細(xì)胞對靶細(xì)胞的殺傷，抑制經(jīng)CD2、CD3以及CD8膜分子介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)作用。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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