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產(chǎn)品中心-北京博奧森生物技術(shù)有限公司
Rabbit Anti-TEM1/BF555 Conjugated antibody (bs-2101R-BF555)
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2101R-BF555
英文名稱 Rabbit Anti-TEM1/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的內(nèi)涎蛋白/內(nèi)皮唾液酸蛋白抗體
別    名 Tumor endothelial marker 1 precursor; TEM 1; TEM-1; tumor endothelial marker 1; CD248; Endosialin; Tumor endothelial marker 1; CD164L1; MGC119478; MGC119479. CD164 sialomucin-like 1; CD248_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞凋亡  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TEM 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment.

Function:
May play a role in tumor angiogenesis.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).

Tissue Specificity:
Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.

Post-translational modifications:
O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 57124 Human

Entrez Gene: 70445 Mouse

Entrez Gene: 293669 Rat

Omim: 606064 Human

SwissProt: Q9HCU0 Human

SwissProt: Q91V98 Mouse

Unigene: 195727 Human

Unigene: 29597 Mouse

Unigene: 38806 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

內(nèi)皮唾液酸蛋白(CD248)是近年發(fā)現(xiàn)的人類腫瘤標(biāo)記物之一,在人類多種惡性腫瘤組織中異常高表達(dá),內(nèi)皮唾液酸蛋白對腫瘤細(xì)胞生長、血管生成、浸潤及轉(zhuǎn)移有重要作用。
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