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產(chǎn)品中心-北京博奧森生物技術(shù)有限公司
Rabbit Anti-TFPI/HRP Conjugated antibody (bs-2535R-HRP)
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-2535R-HRP
英文名稱 Rabbit Anti-TFPI/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標(biāo)記的組織因子途徑抑制劑抗體
別    名 Tissue factor pathway inhibitor-1; convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; TFI; TFPI 1; TFPI1; Tissue factor pathway inhibitor; TFPI1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TFPI
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins.

Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Subcellular Location:
Isoform Alpha: Secreted.
Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Mostly in endothelial cells.

Post-translational modifications:
O-glycosylated.

Similarity:
Contains 3 BPTI/Kunitz inhibitor domains.

Database links:

Entrez Gene: 7035 Human

Entrez Gene: 21788 Mouse

Entrez Gene: 29436 Rat

Omim: 152310 Human

SwissProt: P10646 Human

SwissProt: O54819 Mouse

SwissProt: Q02445 Rat

Unigene: 516578 Human

Unigene: 124316 Mouse

Unigene: 447013 Mouse

Unigene: 15795 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組織因子途徑抑制因子(tissue factor pathway in hibitor, TFPI)是組織因子凝血途徑的主要抑制因子, 組織因子途徑抑制因子在諸如動脈粥樣硬化,血管再狹窄,彌漫性血管內(nèi)凝血DIC等方面,有一定的研究價(jià)值。
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