| 產(chǎn)品編號 | bs-2535R-RBITC |
| 英文名稱 | Rabbit Anti-TFPI/RBITC Conjugated antibody |
| 中文名稱 | 羅丹明（RBITC）標(biāo)記的組織因子途徑抑制劑抗體 |
| 別 名 | Tissue factor pathway inhibitor-1; convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; TFI; TFPI 1; TFPI1; Tissue factor pathway inhibitor; TFPI1_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TFPI |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Subcellular Location: Isoform Alpha: Secreted. Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Mostly in endothelial cells. Post-translational modifications: O-glycosylated. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. Database links: Entrez Gene: 7035 Human Entrez Gene: 21788 Mouse Omim: 152310 Human SwissProt: P10646 Human SwissProt: O54819 Mouse Unigene: 516578 Human Unigene: 124316 Mouse Unigene: 447013 Mouse Unigene: 15795 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 組織因子途徑抑制因子(tissue factor pathway in hibitor, TFPI)是組織因子凝血途徑的主要抑制因子， 組織因子途徑抑制因子在諸如動脈粥樣硬化，血管再狹窄，彌漫性血管內(nèi)凝血DIC等方面，有一定的研究價值。 |
