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產(chǎn)品中心-北京博奧森生物技術(shù)有限公司
Rabbit Anti-WBSCR14/APC Conjugated antibody (bs-3516R-APC)
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3516R-APC
英文名稱 Rabbit Anti-WBSCR14/APC Conjugated antibody
中文名稱 APC標(biāo)記的糖類應(yīng)答元件結(jié)合蛋白ChREBP抗體
別    名 ChREBP; bHLHd14; Carbohydrate responsive element binding protein; MIO; MLX interacting protein like; Mlx interactor; MLXIPL; MONDOB; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; WS basic helix loop helix leucine zipper protein; WS bHLH; MLXPL_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human WBSCR14/ChREBP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain. ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of phospho-serine 196.

Function:
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).

Subunit:
Binds DNA as a heterodimer with TCFL4/MLX.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

Post-translational modifications:
Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity (By similarity).

DISEASE:
Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 51085 Human

Omim: 605678 Human

SwissProt: Q9NP71 Human

Unigene: 647055 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ChREBP(又稱碳水化合物反應(yīng)元件結(jié)合蛋白)是葡萄糖信號途徑中的一個新的轉(zhuǎn)錄因子,在哺乳動物體內(nèi)可結(jié)合到糖酵解和脂肪合成酶相關(guān)基因啟動子區(qū)的糖類應(yīng)答元件(ChRE)上, 在他們的共同作用下,可調(diào)節(jié)糖酵解和脂肪合成酶相關(guān)基因的表達.
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